A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.

MAURICIO R. GALIANO; SMITA JHA; TAMMY SZUYU HO; CHUANSHENG ZHANG; YASUHIRO OGAWA; KAE-JIUN CHANG; MICHAEL C. STANKEWICH; PETER J. MOHLER; MATTHEW N. RASBAND

CELL PRESS

Lugar: United States; Año: 2012 p. 1125 - 1125

nkyrinG (ankG) is highly enriched in neurons at axon initial segments (AIS) where it clusters Na+ and K+ channels and maintains neuronal polarity. How ankG becomes concentrated at the AIS is unknown. Here, we show that as neurons break symmetry, they assemble a distal axonal submembranous cytoskeleton comprised of ankyrinB (ankB), >ababab